Support the vascular systems that help move oxygen and nutrients throughout the body with clinically studied Calabrian bergamot polyphenols that promote endothelial function, healthy circulation, and cardiometabolic balance.
Healthy cardiovascular function depends on the coordinated performance of the heart, vascular endothelium, blood flow, lipid transport, and the body’s oxidative and inflammatory defenses. Bergamonte® provides a multi-pathway approach, using a standardized spectrum of Calabrian bergamot polyphenols to support the systems that help maintain healthy circulation and vascular function.
Clinically Studied
Supported by human clinical research evaluating cardiovascular and cardiometabolic markers.
Standardized Polyphenols
Standardized to a defined spectrum of bergamot flavonoids, including melitidin and brutieridin.
Multi-Pathway Science
Studied across pathways involving lipid metabolism, vascular responsiveness, oxidative stress, and inflammatory signaling.
Calabrian Citrus Source
Derived from Citrus bergamia Risso grown in Calabria, Italy, and distinct from stimulant-oriented Citrus aurantium.
Cardiovascular wellness involves more than a single measurement. Bergamonte® supports interconnected pathways involved in vessel function, circulation, inflammatory balance, and cardiometabolic health.
Key Clinical Benefits
Healthy circulation delivers oxygen and nutrients throughout the body while supporting normal tissue function. Human research on bergamot polyphenols has evaluated vascular responsiveness and flow-mediated vasodilation as measures related to healthy blood flow.
Bergamonte® has been evaluated across cholesterol, triglycerides, glucose, endothelial responsiveness, and oxidative vascular markers. Together, these areas support the interconnected systems involved in cardiovascular wellness.
Human research has measured hs-CRP alongside TNF-α, lipid markers, glucose, and liver biomarkers. These findings support formulations designed to help maintain a healthy inflammatory environment already within the normal range.
Published human research provides a broader view of cardiovascular wellness, with studies evaluating circulating lipids alongside vascular responsiveness, nitric oxide and other cardiometabolic markers.
A 120-day human study used NMR spectroscopy to look beyond standard cholesterol values and examine lipoprotein particle size and concentration. BPF supplementation was associated with fewer IDL and small LDL particles and increases in large LDL and large HDL particles.
Why it matters: Adds a deeper layer of cardiovascular insight.
A 30-day clinical study evaluated BPF across lipid and vascular oxidative markers. Along with changes in the lipid profile, researchers reported reductions in MDA, LOX-1 and phosphoPKB, extending the evidence beyond circulating cholesterol alone.
Why it matters: Broadens the evidence beyond traditional lipid endpoints.
Why it matters: Connects the research to healthy vascular function and circulation.
Why it matters: Provides a concise measure of overall lipid-related risk balance.
Data shown are drawn from separate published human studies using different Bergamonte®/BPF preparations, intake levels, study populations and protocols. Certain clinical formulations included additional components. Results should be interpreted within the context of each individual study and should not be assumed to apply interchangeably across all Bergamonte® ingredients.
Modern cardiovascular health goes well beyond maintaining a healthy cholesterol number. Vascular responsiveness, circulation, glucose metabolism, oxidative balance, and inflammatory signaling all interact with lipid metabolism to influence overall cardiovascular function. That broader view is increasingly important for formulations positioned around proactive heart health, healthy aging, and cardiometabolic wellness.
Bergamonte® fits this systems-based approach particularly well because its research program spans several of these areas rather than concentrating on a single endpoint. This gives formulators the ability to create a more complete cardiovascular story while still grounding the product in a recognizable, standardized botanical ingredient.
Bergamonte® gives formulators a differentiated cardiovascular platform with defined Calabrian polyphenols, patented processing, and human research across multiple heart and vascular endpoints.
Cardiovascular formulations can approach the category through lipid metabolism, vascular responsiveness, circulation or nitric oxide support. Several Bergamonte® options address different parts of that spectrum, allowing ingredient selection to follow the specific cardiovascular positioning of the finished product.
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