Support a balanced lipid profile with clinically studied Calabrian bergamot polyphenols that help maintain healthy LDL, HDL, and triglyceride levels already within the normal range.
A complete cholesterol story extends beyond a single number. Product developers need science that addresses the relationships among LDL, HDL, triglycerides, cholesterol production, and the pathways the body uses to transport and eliminate lipids. Bergamonte® combines a standardized spectrum of Calabrian bergamot polyphenols with human clinical research across these interconnected measurements, creating a differentiated platform for modern cholesterol-support formulas.
Multiple Lipid Markers
Human studies have evaluated total cholesterol, LDL-C, HDL-C, triglycerides, and lipoprotein particle distribution.
Distinctive Polyphenols
Contains a standardized profile that includes naringin, neohesperidin, neoeriocitrin, melitidin, and brutieridin.
Complementary Pathways
Studied across pathways involved in cholesterol production, lipid metabolism, transport, and elimination.
Dose-Responsive Research
Clinical research has evaluated multiple daily intake levels to assess how lipid measurements responded over time.
LDL, HDL, and triglycerides each have distinct roles in lipid transport and metabolism. Bergamonte® supports these related measurements as part of a more complete approach to maintaining a healthy cholesterol profile already within the normal range.
Key Clinical Benefits
LDL particles transport cholesterol through the bloodstream to tissues where it can be used for normal cellular functions. Bergamonte® supports healthy LDL levels through polyphenol-driven pathways associated with endogenous cholesterol production, LDL receptor activity, and cholesterol utilization.
HDL participates in the transport of cholesterol away from peripheral tissues and back to the liver for processing. Human studies of Bergamot Polyphenolic Fraction have reported increases in HDL-C and favorable changes in total and large HDL particle measurements, supporting a balanced lipid profile.
Triglycerides store and transport energy throughout the body, but maintaining them within a healthy range is an important part of cardiometabolic wellness. Bergamonte® supports healthy triglyceride metabolism through pathways involving lipolysis, AMPK activity, lipid transport, and liver cholesterol utilization.
Human studies of bergamot polyphenol formulations have evaluated more than total cholesterol alone, including LDL-C, HDL-C, triglycerides and lipoprotein particle distribution. Together, the research provides a broader view of how standardized bergamot has been studied in relation to healthy lipid balance.
A foundational 30-day human study evaluated BPF at 500 mg/day and 1,000 mg/day alongside placebo. Both BPF groups showed favorable changes across total cholesterol, LDL-C, HDL-C and triglycerides, with the higher intake generally producing the larger response.
Why it matters: A clear dose-response was observed across multiple lipid markers.
A 30-day study of 77 participants compared placebo, two rosuvastatin doses, BPF and BPF plus rosuvastatin. BPF alone was associated with favorable changes in total cholesterol, LDL-C, HDL-C and triglycerides, while the combination produced an even stronger overall lipid response than rosuvastatin 10 mg alone.
Why it matters: The study demonstrates lipid activity both independently and within a combination protocol.
A 120-day BPF study went beyond conventional cholesterol measurements to examine lipoprotein particle distribution. Researchers reported fewer IDL and small LDL particles together with increases in large LDL, total HDL and large HDL particles after supplementation.
Why it matters: The research extends the cholesterol story from concentration to particle distribution.
A 90-day randomized, double-blind study evaluated pectin-enriched BPE-C at 650 mg/day and 1,300 mg/day. Both intake levels produced favorable changes in total cholesterol, LDL-C, HDL-C and triglycerides, with the higher dose showing the strongest overall lipid response.
Why it matters: A separate full-spectrum formulation showed a broad, dose-related lipid response.
Study results reflect the specific bergamot formulations, intake levels, populations and durations evaluated. Certain protocols included ascorbic acid and/or comparator therapies. Results should not be assumed to apply interchangeably across all Bergamonte® ingredient options.
Cholesterol performs essential roles throughout the body, from supporting cell membranes to serving as a precursor for hormones and bile acids. The goal of a modern cholesterol formula is therefore not simply to focus on one number, but to support healthy lipid transport and metabolism across LDL, HDL, triglycerides, and the particles that carry them through circulation.
Bergamonte® is especially relevant to this more nuanced approach because its research includes both conventional lipid measurements and advanced lipoprotein analysis. For brands competing in an established cholesterol category, that additional depth creates an opportunity to build a more differentiated, science-forward product story.
Bergamonte® stands apart from generic cholesterol ingredients through its defined polyphenol profile, multiple standardizations, and research extending beyond basic lipid measurements.
Healthy cholesterol is one of the most established areas of research within the BPF® platform, but the portfolio offers several levels of standardization and formulation flexibility. The best choice depends on desired flavanone density, serving size and how closely the finished formula is intended to align with a particular clinical study.
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