A concentrated 1:1 botanical complex of Calabrian bergamot and wild Cynara cardunculus, standardized to ≥34% total polyphenols and ≥10% cynaropicrin for liver, healthy weight and cardiometabolic formulations.
The liver plays a central role in lipid processing, glucose regulation and energy metabolism, making liver health an important part of the wider metabolic picture. Bergacyn® combines concentrated Calabrian bergamot with wild cardoon to bring both polyphenols and cynaropicrin into one standardized botanical system designed for liver and cardiometabolic formulations.
Why it matters: The direct four-group comparison shows the added value of bringing bergamot and wild cardoon together in one research-backed formulation.
A 12-week randomized, double-blind, placebo-controlled trial recruited 102 adults with hepatic steatosis, with 80 included in the on-treatment analysis. Participants received placebo or a formulation providing approximately 300 mg/day Bergacyn® + 300 mg/day BergaFlow™.
Compared with placebo, the active formulation produced greater changes in all three measures: body weight decreased by 4.2 kg versus 2.7 kg, BMI by 1.6 versus 0.9, and CAP score by 48.2 dB/m versus 26.9 dB/m.
Why it matters: One clinical protocol connects healthy liver fat metabolism with meaningful changes in body weight and BMI.
Study note: The published 90-day trial evaluated the pectin-enriched BPE-C formulation at the Study note: The human studies shown in this section evaluated multi-component bergamot + wild cardoon research formulations rather than Bergacyn® as an isolated ingredient. Published protocols varied by study and incorporated a bergamot-derived fiber component. Findings should be interpreted in the context of the specific formulation, dose, population and protocol evaluated. doses. Forty-five participants completed the intervention, with 15 participants per group. Findings are specific to the studied formulation, doses, population and clinical protocol and should not be generalized to other Bergamonte® ingredient variations.
1. Ferro Y, Montalcini T, Mazza E, Foti D, Angotti E, Gliozzi M, Nucera S, Paone S, Bombardelli E, Aversa I, Musolino V, Mollace V, Pujia A...
2.Musolino V, Gliozzi M, Bombardelli E, Nucera S, Carresi C, Maiuolo J, et al. The synergistic effect of Citrus bergamia and Cynara cardunculus...
3. Ferro Y, Maurotti S, Mazza E, Pujia R, Sciacqua A, Musolino V, Mollace V, Pujia A, Montalcini T. Citrus Bergamia and Cynara Cardunculus ...
Bergacyn® was developed around the close relationship between liver function and cardiometabolic health, giving formulas credible relevance to liver fat metabolism, healthy body weight, lipid balance and oxidative health.
Bergacyn® combines two concentrated botanical extracts in a defined 1:1 composition, giving formulators control over both the extract system and the amount of bergamot fiber used in the finished formula.
Bergacyn® is positioned as a concentrated liver and cardiometabolic botanical system for products that want to address liver health within the context of weight and metabolic wellness.
Healthy liver function and liver fat metabolism provide the clearest lead territory, while healthy weight, lipid metabolism and antioxidant support broaden the application. Its concentrated extract format also gives brands the flexibility to build the clinically researched bergamot-cardoon-fiber architecture while retaining control over the fiber component of the finished product.
Bergacyn® is a proprietary 1:1 combination of Calabrian Citrus bergamia fruit extract and Cynara cardunculus leaf extract, standardized to at least 34% total polyphenols and 10% cynaropicrin.
Bergamot contributes polyphenols with established relevance to lipid and metabolic health, while wild cardoon supplies cynaropicrin and complementary liver-health phytochemistry. The combination has also been investigated directly against the individual botanical components.
The published clinical formulations used the concentrated Bergacyn® extract system together with a bergamot-derived fiber component. Pairing Bergacyn® with BergaFlow™ provides the basic botanical architecture used in those studies.
Bergacyn® is the concentrated 50:50 bergamot and cardoon extract system. Bergacyn® FF incorporates bergamot albedo fiber directly into the ingredient, providing the extract-and-fiber system in a single formulation.
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