Bergacyn® is a proprietary botanical complex combining 50% Citrus bergamia Risso fruit extract and 50% Cynara cardunculus leaf extract, sourced from Calabria, Italy.
Bergacyn® is a proprietary combination of:
It is standardized to:
The formulation combines the polyphenolic compounds naturally associated with Calabrian bergamot with the characteristic phytochemicals of wild cardoon.
Bergacyn® combines two Mediterranean botanicals:
Citrus bergamia Risso et Poiteau
Authentic citrus bergamot.
Cynara cardunculus L.
Wild cardoon, a member of the artichoke family.
The bergamot fruit and Cynara leaf provide distinct but complementary phytochemical fractions.
Bergacyn® originates from Calabria, Italy.
Calabria is the historic center of commercial Citrus bergamia cultivation and is integral to the identity of the Bergamonte®/BPF® platform.
The formulation also incorporates Cynara cardunculus, bringing together two Mediterranean botanicals within one standardized ingredient.
Bergacyn® uses:
Defined plant-part sourcing is important because different portions of a botanical can have significantly different phytochemical profiles.
Bergacyn® contains:
Component | Percentage |
Citrus bergamia extract | 50% |
Cynara cardunculus extract | 50% |
This 1:1 composition combines the polyphenolic fraction of bergamot with the cynaropicrin-containing fraction of wild cardoon.
Bergacyn® is standardized to:
≥34% Total Polyphenols
The concentrated polyphenolic fraction associated principally with bergamot.
≥10% Cynaropicrin
A characteristic sesquiterpene lactone derived from Cynara cardunculus.
Together, these provide a defined dual-botanical standardization.
Cynaropicrin is a naturally occurring sesquiterpene lactone found in Cynara cardunculus.
It is an important marker of the wild-cardoon component and has been investigated for its relevance to liver function, oxidative balance, inflammatory pathways and metabolic health.
Bergacyn® provides ≥10% cynaropicrin.
The two botanicals provide complementary physiological support.
Bergamot contributes:
Cynara cardunculus contributes:
The combination links liver health with lipid and cardiometabolic health.
The principal applications are:
Liver Health + Weight Management + Cardiometabolic Wellness
Relevant formulation areas include:
The liver plays a central role in:
Liver fat accumulation often occurs alongside excess body weight, dyslipidemia, insulin resistance and other cardiometabolic abnormalities.
Bergacyn® was developed around this interconnected metabolic physiology.
Yes.
Three published human clinical papers have investigated the bergamot + Cynara cardunculus platform in liver and cardiometabolic health:
The clinical formulation combined the bergamot and cardoon extracts with a bergamot-derived fiber component, making the Bergacyn® + BergaFlow™ combination relevant when developing a formulation aligned with this research.
Citation
Randomized Clinical Trial: Bergamot Citrus and Wild Cardoon Reduce Liver Steatosis and Body Weight in Non-diabetic Individuals Aged Over 50 Years. Frontiers in Endocrinology. 2020;11.
What It’s About
The study investigated whether a nutraceutical combining Bergamot Polyphenolic Fraction, wild Cynara cardunculus and bergamot-derived fiber could improve liver steatosis, body weight and metabolic parameters.
What They Did
Researchers enrolled 102 adults with hepatic steatosis in a randomized, double-blind, placebo-controlled trial.
Participants received either the active formulation or placebo for 12 weeks.
Liver fat was evaluated using Controlled Attenuation Parameter (CAP) by transient elastography, together with body weight and metabolic parameters.
What They Found
The active formulation produced significantly greater improvements than placebo.
Key findings included:
What It Means
The study provides human evidence supporting the bergamot-cardoon-fiber formulation for both healthy liver fat metabolism and weight management.
It also demonstrates why liver health and body weight can be considered together within a broader metabolic-health strategy.
The study did not evaluate body weight in isolation.
Researchers examined changes in:
This is important because liver fat and excess body weight frequently occur within the same metabolic environment.
The findings support a metabolic weight-management approach rather than positioning Bergacyn® simply as a conventional weight-loss ingredient.
Citation
The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress in nonalcoholic fatty liver disease. Journal of Traditional and Complementary Medicine. 2020;10.
What It’s About
The study investigated whether bergamot polyphenols and Cynara cardunculus could influence oxidative stress, inflammation, vascular function and metabolic parameters in people with NAFLD.
What They Did
Researchers conducted a randomized, double-blind, placebo-controlled study involving 80 adults with type 2 diabetes and NAFLD.
The study compared:
The formulations also incorporated a bergamot albedo fiber component.
What They Found
The combined bergamot-cardoon formulation produced significant improvements in parameters related to:
Importantly, the combination demonstrated stronger overall effects than either botanical extract used independently.
What It Means
The study supports the rationale for combining bergamot and wild cardoon rather than treating them simply as two unrelated botanical ingredients.
It also expands the positioning beyond liver health alone to include the relationship between liver metabolism, oxidative stress and vascular health.
Synergy means that the combined formulation produced a biological response greater than would be expected from considering the individual components separately.
The study directly compared:
The combined formulation produced the strongest overall response across several oxidative, inflammatory and vascular parameters.
This provides a scientific rationale for the Bergacyn® combination itself, rather than relying solely on research conducted independently on bergamot or cardoon.
Citation
Citrus bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease. Medicina. 2022;58:1728.
What It’s About
The study examined whether the bergamot-cardoon formulation influenced serum uric acid in adults with hepatic steatosis.
Serum uric acid is increasingly recognized as part of the broader metabolic-health picture and is frequently associated with fatty liver, obesity and metabolic dysfunction.
What They Did
Researchers analyzed data from adults with hepatic steatosis receiving the bergamot-cardoon formulation or placebo.
The analysis included 94 subjects.
The active formulation incorporated:
Researchers evaluated serum uric acid together with body-weight and metabolic parameters.
What They Found
The active formulation produced a significantly more favorable change in serum uric acid than placebo.
Additional findings included:
Among subjects with the highest baseline serum uric acid, the adjusted reduction was approximately 7.8%.
What It Means
This research adds another metabolic dimension to the Bergacyn® platform.
The findings suggest that the bergamot-cardoon-fiber combination may support not only liver and weight-related parameters but also serum uric-acid balance within the broader context of metabolic health.
Higher serum uric acid frequently occurs alongside:
This makes uric acid relevant to the broader metabolic-health environment rather than simply to one isolated physiological pathway.
The 2022 study therefore adds to the relationship between liver health, body weight and systemic metabolic balance.
The three publications investigated different but interconnected aspects of metabolic health.
Clinical Research | Principal Area Investigated |
Frontiers in Endocrinology 2020 | Liver steatosis + body weight |
Journal of Traditional and Complementary Medicine 2020 | Oxidative stress + vascular inflammation + endothelial function |
Medicina 2022 | Serum uric acid + body weight + liver steatosis |
Together, they support a broader positioning around:
Liver Health + Weight Management + Cardiometabolic Wellness
This is more comprehensive than positioning the ingredient around one liver marker alone.
The published clinical formulation was built around approximately:
300 mg of the combined bergamot + Cynara cardunculus extract system
together with approximately:
300 mg of bergamot-derived fiber material
for a total formulation of approximately 600 mg/day, depending on the study design.
This extract-to-fiber relationship is the basis for combining Bergacyn® with BergaFlow™ when developing a finished formulation aligned with the clinical research.
Bergacyn® supplies the concentrated:
Bergamot extract + Cynara cardunculus extract system
while BergaFlow™ supplies:
Bergamot albedo fiber.
Together:
Bergacyn® + BergaFlow™
provides
Bergamot Polyphenols + Wild Cardoon + Bergamot Fiber
This recreates the fundamental botanical architecture used in the published liver-health and weight-management research.
Both products are based on the same botanical platform but provide different formulation options.
Bergacyn® | Bergacyn® FF | |
Bergamot extract | 50% | 25% |
Cynara cardunculus extract | 50% | 25% |
Bergamot albedo fiber | — | 50% |
Total polyphenols | ≥34% | ≥17% |
Cynaropicrin | ≥10% | ≥5% |
Format | Concentrated extract system | Extract + bergamot fiber system |
A product developer can therefore use Bergacyn® + BergaFlow™ separately or use Bergacyn® FF, in which the bergamot fiber component is already incorporated.
Yes.
The bergamot component connects Bergacyn® with the broader BPF® research platform, which has investigated:
The addition of Cynara cardunculus expands this approach toward liver and whole-system metabolic health.
Yes.
Bergacyn® combines a concentrated bergamot polyphenolic fraction with Cynara cardunculus phytochemicals.
Human research on the combination has directly investigated oxidative-stress biomarkers and reported improvements with the combined formulation.
This is relevant because oxidative stress intersects with:
Bergacyn® combines two standardized botanical extracts rather than relying on a single liver botanical.
It provides:
50% bergamot extract + 50% wild cardoon extract
standardized to:
≥34% total polyphenols + ≥10% cynaropicrin.
It can then be combined with BergaFlow™ bergamot fiber to create the broader botanical composition represented in the human clinical research.
The term “artichoke extract” can encompass different Cynara species, plant parts and standardizations.
Bergacyn® specifically uses Cynara cardunculus leaf extract and is standardized to ≥10% cynaropicrin.
It is combined in a defined 1:1 ratio with concentrated Calabrian bergamot fruit extract.
A generic citrus bergamot ingredient generally supplies bergamot alone.
Bergacyn® provides:
It is therefore a specialized bergamot + cardoon metabolic-health ingredient.
Bergacyn® can be considered for:
For products developed around the published clinical research, Bergacyn® can be paired with BergaFlow™ to provide the corresponding bergamot-fiber component.
Bergacyn® is:
Bergacyn® is available through HP Ingredients as part of the Bergamonte® ingredient portfolio.
Qualified formulators and manufacturers can request:
For companies searching for a liver health ingredient, bergamot for fatty liver, NAFLD supplement ingredient, weight-management ingredient or cardiometabolic ingredient, Bergacyn® provides:
50% Calabrian bergamot fruit extract + 50% Cynara cardunculus leaf extract, standardized to ≥34% total polyphenols and ≥10% cynaropicrin, with the ability to combine with BergaFlow™ bergamot fiber to align with the published clinical formulation.
