THE SCIENCE
14 Published Human Clinical Trials and Counting…
Bergamonte® BPE Complex™ is a unique citrus extract from Calabria, Italy, different than Citrus aurantium from China or other countries. There are now over 200 research papers published on Bergamot Polyphenols with over 12 published human clinical studies on Bergamonte®, showing efficacy in several parameters of metabolic syndrome, including cardiometabolic risk, cholesterol and NAFLD, making Bergamonte® BPE Complex™ highly relevant for nearly 50 million Americans. In addition, for those who would rather not take statins for cholesterol management, Bergamonte® BPE Complex™ may be an effective alternative, or an adjunct, depending upon the individual.
Cholesterol & Metabolic Syndrome
1. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies
Fitoterapia Volume 82, Issue 3, April 2011, Pages 309-316
Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli, Salvatore Ragusa, Carolina Muscoli, Domenicantonio Rotiroti, Franco Romeo
2. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDLcholesterol, LOX-1 expression and Protein Kinase B phosphorylation in patients with hyperlipidemia
International Journal of Cardiology November 14, 2013
Micaela Gliozzi, Ross Walker, Saverio Muscoli, Cristiana Vitale, Santo Gratteri, Cristina Carresi,
Vincenzo Musolino, Vanessa Russo, Elzbjeta Janda, Salvatore Ragusa, Antonio Aloe, Ernesto
Palma, Carolina Muscoli, Franco Romeo and, Vincenzo Mollace
3. Bergamot Polyphenols: Pleiotropic Players in the Treatment of Metabolic Syndrome
4. Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
5. The effect of bergamot polyphenolic fraction on lipid transfer protein system and vascular oxidative stress in a rat model of hyperlipemia
Lipids in Health and Disease (2019) 18:115
Vincenzo Musolino, Micaela Gliozzi, Saverio Nucera, Cristina Carresi, Jessica Maiuolo, Rocco Mollace,
Sara Paone, Francesca Bosco, Federica Scarano, Miriam Scicchitano, Stefano Ruga, Maria Caterina Zito,
Carmen Colica, Roberta Macrì, Ernesto Palma, Salvatore Ragusa, Carolina Muscoli and
Vincenzo Mollace
Healthy Liver
1. The Effect of Bergamot-Derived Polyphenolic Fraction on LDL Small Dense Particles and Non Alcoholic Fatty Liver Disease in Patients with Metabolic Syndrome
Advances in Biological Chemistry Jan 2014
Micaela Gliozzi, Cristina Carresi, Vincenzo Musolino, Ernesto Palma, Carolina Muscoli, Cristiana Vitale, Santo Gratteri, Giuseppe Muscianisi, Elzbieta Janda, Saverio Muscoli, Francesco Romeo, Salvatore Ragusa, Rocco Mollace, Ross Walker, James Ehrlich, Vincenzo Mollace*
2. Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity
Nutrients Nov 2018
Maddalena Parafati, Antonella Lascala, Daniele La Russa, Chiara Mignogna, Francesca Trimboli, Valeria Maria Morittu, Concetta Riillo, Rachele Macirella, Vincenzo Mollace, Elvira Brunelli and Elzbieta Janda
Healthy Weight Management
1. Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols
Nutrients 2019, 11, 1271
Antonio Soccorso Capomolla, Elzbieta Janda, Sara Paone, Maddalena Parafati, Tomasz Sawicki, Rocco Mollace, Salvatore Ragusa and Vincenzo Mollace
2. Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction
Antioxidants (Basel). 2019 Mar; 8(3): 66.
Daniele La Russa, Francesca Giordano, Alessandro Marrone, Maddalena Parafati, Elzbieta Janda and Daniela Pellegrino
3. Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols
Nutrients 2019, 11, 1271
Antonio Soccorso Capomolla, Elzbieta Janda, Sara Paone, Maddalena Parafati, Tomasz Sawicki, Rocco Mollace, Salvatore Ragusa and Vincenzo Mollace
Cognition
1. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia. Data From an 8-Week, Open-Label Pilot Study
Journal of Clinical Psychopharmacology: August 2017 – Volume 37 – Issue 4 – p 468-471
Antonio Bruno, MD, PhD, Gianluca Pandolfo, MD, PhD, Manuela Crucitti, MD, Clemente Cedro, MD, PhD,
Rocco Antonio Zoccali, MD, and Maria Rosaria Anna Muscatello, MD, PhD
2. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia. Data From an 8-Week, Open-Label Pilot Study
Journal of Clinical Psychopharmacology: August 2017 – Volume 37 – Issue 4 – p 468-471
Antonio Bruno, MD, PhD, Gianluca Pandolfo, MD, PhD, Manuela Crucitti, MD, Clemente Cedro, MD, PhD, Rocco Antonio Zoccali, MD, and Maria Rosaria Anna Muscatello, MD, PhD
https://journals.lww.com/psychopharmacology/Abstract/2017/08000/Bergamot_Polyphenolic_Fraction_Supplementation.17.aspx
Antioxidant/Anti-inflammatory
1. Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury
Frontiers in Pharmacology July 2016
Daniela Impellizzeri, Marika Cordaro, Michela Campolo, Enrico Gugliandolo, Emanuela Esposito, Filippo Benedetto, Salvatore Cuzzocrea, and Michele Navarra
2. Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and ckitpos CD45neg CD31neg cardiac stem cell activation
Journal of Molecular & Cellular Cardiology, VOLUME 119, P10-18, JUNE 01, 2018
Cristina Carresi, Vincenzo Musolino, Micaela Gliozzi, Jessica Maiuolo, Rocco Mollace, Saverio Nucera, Alessia Maretta, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Ernesto Palma, Francesca Bosco, Caterina Giancotta, Carolina Muscoli, Fabiola Marino, Iolanda Aquila, Daniele Torella, Franco Romeo, Vincenzo Mollace
3. Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations
Food & Science Nutrition 2019 Feb; 7(2): 369–384.
Simone Perna Daniele Spadaccini Leonardo Botteri Carolina Girometta, Antonella Riva Pietro Allegrini Giovanna Petrangolini Vittoria Infantino, Mariangela Rondanelli
4. Antioxidant and Antisenescence Effects of Bergamot Juice
Oxidative Medicine & Cellular Longevity 2018; 2018: 9395804.
Eleonora Da Pozzo, Marinella De Leo, Immacolata Faraone, Luigi Milella, Chiara Cavallini, Eugenia Piragine, Lara Testai, Vincenzo Calderone, Luisa Pistelli, Alessandra Braca, and Claudia Martini
5. Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury
Daniela Impellizzeri, Marika Cordaro, Michela Campolo, Enrico Gugliandolo,
Emanuela Esposito, Filippo Benedetto, Salvatore Cuzzocrea and Michele Navarra
6. Qualitative and quantitative analysis of the Proautophagic activity of Citrus flavonoids from Bergamot Polyphenol Fraction
Data in Brief, Volume 19, August 2018, Pages 1327-1334
Elzbieta Janda, Raffaele Salerno, Concetta Martino, Antonella Lascala, Daniele LaRussa, Manuela Oliverio
Other Benefits
1. Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signaling and mitochondrial metabolism
Biochimica et Biophysica Acta – Bioenergetics Volume 1859, Issue 9, September 2018, Pages 984-996
Marco Fiorillo, Maria Peiris-Pagès, Rosa Sanchez-Alvarez, Lucia Bartella, Leonardo Di Donna, Vincenza Dolce, Giovanni Sindona, Federica Sotgia, Anna Rita Cappello, Michael P. Lisanti
2. Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice
PLoS One. 2016
Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino, Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli, Maurizio Muraca, Bianca M. Goffredo, Vincenzo Mollace, Carolina Muscoli
3. Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats
Frontiers in Pharmacology 2018; 9: 1563.
Enrico Gugliandolo, Roberta Fusco, Ramona D’Amico, Matteo Peditto, Giacomo Oteri, Rosanna Di Paola, Salvatore Cuzzocrea and Michele Navarra
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